Guan-Lei Wang Selected Research

xyloketal B

1/2022	Xyloketal B: A marine compound with medicinal potential.
12/2018	Marine Compound Xyloketal B as a Potential Drug Development Target for Neuroprotection.
9/2017	Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-κB inflammatory signaling pathway.
4/2015	Xyloketal B suppresses glioblastoma cell proliferation and migration in vitro through inhibiting TRPM7-regulated PI3K/Akt and MEK/ERK signaling pathways.
4/2015	Xyloketal B attenuates atherosclerotic plaque formation and endothelial dysfunction in apolipoprotein e deficient mice.
12/2014	Marine compound xyloketal B reduces neonatal hypoxic-ischemic brain injury.
2/2013	Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish.
12/2009	Marine compound Xyloketal B protects PC12 cells against OGD-induced cell damage.
10/2009	A novel marine compound xyloketal B protects against oxidized LDL-induced cell injury in vitro.

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Guan-Lei Wang Research Topics

Disease

9	Hypertension (High Blood Pressure) 01/2022 - 06/2007
6	Cardiovascular Diseases (Cardiovascular Disease) 11/2022 - 03/2009
4	Vascular Remodeling 01/2022 - 01/2019
4	Stroke (Strokes) 12/2018 - 03/2009
4	Ischemia 12/2018 - 12/2009
3	Atherosclerosis 11/2022 - 10/2009
3	Brain Injuries (Brain Injury) 05/2018 - 12/2014
3	Type 2 Diabetes Mellitus (MODY) 01/2017 - 11/2014
2	Thrombosis (Thrombus) 10/2022 - 12/2021
2	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 04/2015
2	Body Weight (Weight, Body) 12/2019 - 01/2017
2	Ischemic Stroke 12/2018 - 12/2009
1	Stable Angina 11/2022
1	Cystic Fibrosis (Mucoviscidosis) 10/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Hemorrhage 12/2021
1	Obesity 12/2019
1	Lipid Metabolism Disorders (Metabolism Disorders, Lipid) 12/2019
1	Myotoxicity 04/2019
1	Muscular Diseases (Myopathy) 04/2019
1	Glioma (Gliomas) 01/2019
1	Seizures (Absence Seizure) 01/2019
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 05/2018
1	Cerebral Infarction 09/2017
1	Neurologic Manifestations (Neurological Manifestations) 09/2017
1	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 09/2017
1	Atherosclerotic Plaque (Atheroma) 04/2015
1	Infarction (Infarctions) 12/2014
1	Hypoxia (Hypoxemia) 12/2014
1	Hyperlipidemias (Hyperlipidemia) 11/2014
1	Insulin Resistance 11/2014
1	Hyperglycemia 11/2014
1	Neoplasms (Cancer) 01/2012

Drug/Important Bio-Agent (IBA)

9	xyloketal BIBA 01/2022 - 10/2009
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2016
5	Chloride Channels (Chloride Channel)IBA 02/2020 - 02/2012
4	Angiotensin IIIBA 02/2020 - 02/2016
3	Apolipoproteins E (ApoE)IBA 11/2022 - 04/2015
3	ChloridesIBA 01/2022 - 06/2007
3	Glucose (Dextrose)FDA LinkGeneric 12/2019 - 12/2009
3	Pharmaceutical PreparationsIBA 04/2019 - 04/2015
3	Nonesterified Fatty Acids (NEFA)IBA 01/2017 - 11/2014
2	oxidized low density lipoproteinIBA 11/2022 - 10/2009
2	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 10/2013
2	Neuroprotective AgentsIBA 05/2018 - 09/2017
2	PalmitatesIBA 01/2017 - 11/2014
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2017 - 10/2009
2	Sucrose (Saccharose)IBA 01/2017 - 11/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2017 - 01/2012
2	Oxygen (Dioxygen)IBA 12/2014 - 12/2009
1	tezacaftorIBA 11/2022
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 10/2022
1	Adenosine Triphosphate (ATP)IBA 10/2022
1	Ion Channels (Ion Channel)IBA 10/2022
1	Protein Kinases (Protein Kinase)IBA 01/2022
1	Becaplermin (PDGF-BB)FDA Link 01/2022
1	LipidsIBA 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2022
1	isaridin EIBA 12/2021
1	Adenosine Diphosphate (ADP)IBA 12/2021
1	Biomarkers (Surrogate Marker)IBA 04/2019
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 04/2019
1	N-desmethyl rosuvastatinIBA 04/2019
1	rosuvastatin lactoneIBA 04/2019
1	Rosuvastatin Calcium (Crestor)FDA Link 04/2019
1	CollagenIBA 01/2019
1	Fibronectins (Fibronectin)IBA 01/2019
1	Metalloproteases (Metalloproteinases)IBA 01/2019
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2019
1	multidrug resistance-associated protein 1IBA 01/2019
1	BestrophinsIBA 01/2019
1	AnionsIBA 01/2019
1	AcidsIBA 05/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2017
1	ClC-3 channelIBA 10/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 04/2015
1	Therapeutic UsesIBA 04/2015
1	ApolipoproteinsIBA 04/2015
1	Desoxycorticosterone Acetate (DOCA)FDA Link 10/2013
1	SaltsIBA 10/2013
1	EnzymesIBA 02/2013
1	AntioxidantsIBA 02/2013
1	Heme Oxygenase-1IBA 02/2013
1	Kv1.5 Potassium ChannelIBA 01/2012
1	Calcium Channels (Calcium Channel)IBA 03/2009
1	SaponinsIBA 03/2009
1	Endothelin-1 (Endothelin 1)IBA 03/2009
1	ginsenoside RdIBA 03/2009

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2019
1	Injections 09/2017
1	Surgical Instruments (Clip) 03/2009